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Review Article

티로신 키나아제 저해제의 간독성에 대한 고찰

원문정보

Reviews on the Hepatotoxicity of Tyrosine Kinase Inhibitors

한지민, 곽혜선

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

Background: Small-molecule tyrosine kinase inhibitors (TKIs) have had major impacts on anticancer therapy by targeting the catalytic activities of dysregulated tyrosine kinases. TKIs have not presented traditional toxicities; however, some serious adverse effects, including hepatotoxicity, have been documented in clinical trials and post-marketing surveillance. Although TKI-induced hepatotoxicity can cause severe clinical complications in patients, the underlying mechanism is still unclear. Methods: Studies on TKI-induced hepatotoxicity were identified by Pubmed search, and relevant articles were reviewed. Results: Immunoallergic reaction, cytochrome P (CYP) 450 polymorphisms, and formation of reactive metabolites are under consideration as mechanisms of TKI-induced hepatotoxicity. Host protein-drug metabolite conjugates are recognized as antigens by class II major histocompatibility complexes and are believed to cause liver injuries. Polymorphisms in CYP, which influences TKI metabolism, can slow TKI metabolism and may induce development of hepatotoxicity. The formation of reactive metabolites during drug metabolism can induce hepatotoxicity by directly causing cytotoxicity, leading to cell dysfunction, and indirect toxicity by mediating secondary immune reactions. Concurrent use of various medications with TKI can also cause hepatotoxicity by affecting drug transporter or enzyme activities. Conclusion: Periodic monitoring of patients taking TKIs and risk/benefit reassessments though post marketing surveillance are necessary to prevent hepatotoxicity.

목차

ABSTRACT
서론
TKI에 의한 간독성 현황과 특징
TKI에 의한 간독성 발생 기전
면역반응
약물대사: CYP의 유전적 다형성
활성대사체 형성
약물상호작용
TKI에 의한 간독성의 모니터링 및 관리
결론
References

저자정보

  • 한지민 Ji Min Han. 이화여자대학교 약학대학
  • 곽혜선 Hye Sun Gwak. 이화여자대학교 약학대학

참고문헌

자료제공 : 네이버학술정보

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