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Original Article

혈당강하제 단독요법 투여 당뇨병환자에서 암발생률 평가 : 후향적 코호트 연구

원문정보

Cancer Risk in Patients with Type 2 Diabetes on Antidiabetic Monotherapy : A Population Based Cohort Study Using National Insurance Health Service Database

정한영, 이숙향

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

Background: Diabetes is associated with cancer risk in the aging population. Observational studies have indicated the beneficial effects of metformin against breast cancer, making studies on the anticancer potential of antidiabetic drugs worthwhile. This study investigated cancer incidence in patients on antidiabetic monotherapy. Methods: Using National Health Insurance Service data (2002-2013), a retrospective cohort study that included type 2 diabetes mellitus (T2DM) patients was conducted. Study subjects were enrolled if they were ≥30 years old, on monotherapy for diabetes, and cancer-free. They were followed up for cancer occurrence or death, until December 31st, 2013. A Cox proportional hazard model analysis was conducted between metformin and sulfonylurea (including meglitinide) users, to determine cancer risk, with adjustment for age, gender, comorbidity index, dyslipidemia, hypertension, and T2DM duration. Results: The number of antidiabetic monotherapy-treated T2DM patients without a history of cancer was 9,554 (metformin, n = 5,825; sulfonylurea, n = 3,225; others, n = 504). During the follow-up period (mean, 2.04; IQR, 3.18 years), the cancer incidence rate was 5.48/100 and 5.45/100 patient-years for metformin and sulfonylurea, respectively. The hazard ratio (HR) for risk of cancer incidence in the metformin group was 0.74 (95% confidence interval [CI], 0.66-0.83; p < 0.0001), compared with sulfonylurea. Additionally, the HRs for risks of lung, liver, and stomach cancer were respectively 0.46 (95% CI, 0.31- 0.66; p < 0.0001), 0.41 (95% CI, 0.31-0.54; p < 0.0001), and 0.51 (95% CI, 0.35-0.73; p = 0.0003). Conclusion: Antidiabetic therapy with metformin reduces cancer risk by 26%, specifically for lung, liver, and stomach cancer.

목차

ABSTRACT
연구 방법
자료원 및 연구대상
평가변수
통계분석
연구 결과
고찰
결론
감사의 글

저자정보

  • 정한영 Han Yeong Jung. 아주대학교 약학대학
  • 이숙향 Sukhyang Lee. 아주대학교 약학대학

참고문헌

자료제공 : 네이버학술정보

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