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Original Article

Effects of a single bout of exercise on mitochondria-mediated apoptotic signaling in rat cardiac and skeletal muscles

원문정보

초록

영어

This study aimed to determine the effects of a single bout exercise on mitochondria-mediated apoptotic signaling in cardiac and skeletal muscles. Fischer 344 rats (4 months old) were randomly divided into the control or a single bout of exercise group (n=10 each). The rats per-formed a single bout of treadmill exercise for 60 min. Mitochondria-me-diated apoptotic signaling (e.g., Bax, Bcl-2, mitochondrial permeability transition pore [mPTP] opening, cytochrome c, and cleaved caspase-3) was measured in cardiac (e.g., left ventricle) and skeletal (e.g., soleus and white gastrocnemius) muscles. A single bout of exercise signifi-cantly decreased mPTP opening sensitivity in all tissues. However, a single bout of exercise did not show any statistical differences in Bax, Bcl-2, cytochrome c, and cleaved caspase-3 in all tissues measured. A single bout of exercise did not show definite results on characteristics of mitochondria-mediated apoptotic signaling. Therefore, further re-search is necessary to provide a more mechanistic understanding of the apoptosis pathway.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experimental design
Animals and ethical approval
Exercise design
Western immunoblot analysis
Statistical analysis
RESULTS
Effects of a single bout of exercise on Bax and Bcl-2 in cardiac and skeletal muscles
Effects of a single bout exercise on mPTP, cytochrome c, and cleaved caspase-3 in cardiac and skeletal muscles
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

저자정보

  • Su-Zi Yoo Department of Kinesiology, Inha University, Incheon, Korea
  • Mi-Hyun No Department of Kinesiology, Inha University, Incheon, Korea
  • Jun-Won Heo Department of Kinesiology, Inha University, Incheon, Korea
  • Eunwook Chang Department of Kinesiology, Inha University, Incheon, Korea
  • Dong-Ho Park Department of Kinesiology, Inha University, Incheon, Korea
  • Ju-Hee Kang Department of Pharmacology and Medicinal Toxicology Research Center, Inha University School of Medicine, Incheon, Korea
  • Dae-Yun Seo National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea
  • Jin Han National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan, Korea
  • Su-Jeen Jung Department of Leisure Sports, Seoil University, Seoul, Korea
  • Kwan Hwangbo Technical & Education Office, Korea Football Association, Seoul, Korea
  • Hyo-Bum Kwak Department of Kinesiology, Inha University, Incheon, Korea

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