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Objectives: The purpose of this study was to determine the effectiveness of hand acupressure in relieving shoulder pain among male manufacturing workers. Methods: A nonequivalent control group was employed using a nonsynchronized design. Data were collected from two manufacturing plants located in metropolitan area U. The data were analyzed with a χ2-test and an independent t-test to perform a homogeneity test, and with repeated ANOVA measures to perform an hypothesis test using the SPSS 21.0 program. Results: Hypothesis 1 that “the experimental group provided with hand moxibustion would score lower for low shoulder pain than the control group” was supported (F=306.05, p<.001). Hypothesis 2, that “the experimental group provided with hand moxibustion would have a wider range of motion than the control group” was also supported with increased flexion(F=7.73, p<.001), extension(F=7.89, p=.001), abduction(F=21.23, p<.001), and horizontal abduction(F=20.89, p=.028). Hypothesis 3, that “the experimental group provided with hand moxibustion would score lower for quality of sleep than the control group” was not supported (F=56.10, p=.091). Conclusions: Hand moxibustion is effective in relieving shoulder pain for male manufacturing workers, in relieving low shoulder pain and increasing the range of motion.