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Objectives: This study is a descriptive research to investigate the predictors of intention to quit smoking in patients with acute coronary syndrome(ACS). Methods: A total of 192 ACS patients hospitalized for an angiogram during symptom management were conveniently recruited from a university hospital cardiovascular care unit. Data were collected from January to December in 2018 and were analyzed using binominal logistic regression. Results: The predictors of intention to quit smoking in patients with ACS were drinking(odds ratio[OR]=0.315, p=.006), experience of smoking cessation education(OR=0.325, p=.007), depression(OR=0.739, p<.001), and smoking-related self-efficacy(OR=1.091 p=.006). Conclusion: The findings suggest that the alleviation of depression and enhancement of smoking-related self-efficacy can prevent recurrence and enhance the treatment of ACS.