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Purpose: This study aimed to investigate the factors affecting general hospital nurses’ intention to stay in their jobs. Methods: A descriptive research design was used with a convenience sample of 286 nurses. Data were collected from March 15 to April 14, 2017using self-reported questionnaires and analyzed by descriptive statistics, t-test, analysis of variance, Pearson’s correlation coefficient, and multiple regression analysis using the SPSS/WIN 21.0 program. Results: The mean scores for intention to stay, resilience, and emotional labor were 5.28 out of 8, 57.40 out of 100, and 3.23 out of 5, respectively. Intention to stay was positively correlated with overall career (r=.30), workplace (r=.18), shift work (r=-.20), position (r=.28), salary (r=.13), job satisfaction (r=.51), hospital satisfaction (r=.46), and resilience (r=.41). Factors influencing the intention to stay were job satisfaction and resilience, which explained 28% of the variance. Conclusion: Overall career, job satisfaction, and resilience are critical factors affecting general hospital nurses’ intention to stay. Based on the findings of this study, efforts to improve nurses’ job satisfaction and resilience should be implemented to mitigate the loss of this expert group among healthcare professionals.