earticle

영어

Aim: Several mechanisms have been proposed as an explanation for the protective action of the physical activity against cancer. Experimental evidences have been suggested, but until now, no particular mechanism has been shown to prevent cancer and increase immune function. The aim of this study was to determine the effects of physical activity on changes in immune function of survivors from colorectal cancer. Materials and Methods: The participants were 6 women, aged between 47 and 59 years, who were recruited from Seoul Song-Do Hospital. All participants were participated in physical activity program 80 minutes a day, 3 times a week for 6.67 ± 3.98 months. Survivors performed 10 minutes of warm-up, 60 minutes of work-out which consisted with aerobic exercise (40 min) and resistance exercise (20 min), and 10 minutes of cool-down. The intensity of physical activity was set 40 to 70% of maximal heart rate. Although the intensity, duration and frequency of physical activity was the same in absolute value, the activity period was different. The reason for the difference in the period of physical activity was that the survivors participated in different periods. This study investigated the changes of CBC, innate immunity related to NK-cell and percentage, adaptive immunity related to T-cell and percentage, and adaptive immunity related to immune suppression. Based on the results of Kolmogorov-Smirnov test, the non-parametric Mann Whitney U test was used to examine the differences of variables within times. The significance was established at P ≤ .05. Results: The 1st section analyzed the CBC which composed of WBC, number and percent of lymphocyte, and number and percent of neutrophil. Following analysis, the number of lymphocyte was significantly increased (Z=-1.992; P=0.046) after physical activity intervention. The 2nd section analyzed the innate immunity related to NK-cell and percentage which composed of NLR, CD3-CD56 NK cell (total NK cell), NKG2D+NK cell, KIR2DL3+NK cell and NKT. There were no significantly different. The 3rd section analyzed the adaptive immunity related to T-cell and percentage which composed of CD3+T cell (total T cell), CD3+CD4+T cell (Helper T cell), CD3+CD8+T cell (Cytotoxic T cell), CD4/CD8 ratio, Th1, Th2, and Th1/Th2 ratio. Following physical activity intervention, the number of Th2 (Z=-2.201; P=0.028) was significantly decreased. The last section analyzed the adaptive immunity related to NK-cell and percentage which composed of CD4+CD25+T cell, CD4+CTLA+4+T cell, CD4+PD1+T cell, CD8+PD1+T cell, CD8+TIGIT+T cell, MDSCs and cytotoxicity. Following physical activity intervention, the number and percentage of CD8+PD1+T cell were significantly decreased (Z=-2.201; P=0.028; Z=-1.992; P=0.046), whereas, the CD8+TIGIT+T cell (Z=-1.992; P=0.046) and cytotoxicity (Z=-1.992; P=0.046) were significantly increased. Conclusion: This study found out that there were some significant changes in adaptive immune function. In other words, this study confirmed that the regular physical activity affected to the adaptive immune function of colorectal cancer survivors.