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C-peptide level is controlled by exercise in childhood obesity

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영어

Childhood obesity has been considered as a disease since it causes problems in insulin regulation, inflammation induction and expression of adipocytokine secretion in childhood. As is well-known, exercise is an essential element in obesity treatment. Here we designed an exercise program to investigate how exercise affects childhood obesity. Non-obesity (n=17) and obesity (n=16) children, aged 11~12, performed the designed exercise program, 3 times per week for 16 weeks. We checked changes in health-related physical fitness of the subjects, as well as insulin-resistance (HOMA-IR) before and after the exercise programs. We also tested blood of the individual subjects, to know how C-peptide, resistin, Insulin-like growth factor 1 (IGF-1) and growth hormone (GH) levels are changed after the exercise program. We found that C-peptide level is 2-fold higher in the obesity group than the non-obesity group before the exercise program unlike other blood serum levels, then the C-peptide level of the obesity group drops down to a normal level similar to the non-obesity group after the 16-weeks exercise program. This evidence suggests that exercise may provide a decisive crucial physiological factor for childhood obesity by regulating body composition and C-peptide for inflammation.

저자정보

  • Min-Seong Ha Laboratory of Exercise Biochemistry and Neuroendocrinology, Faculty of Health and Sports Sciences, University of Tsukuba, Ibaraki, Japan Department of Sports Neuroscience, Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan Laboratory of Exercise Physiology, Department of Physical Education, Pusan National University, Busan, Korea
  • Won-Ki Cho Department of Biological Sciences, College of Life Science & Bioengineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea
  • Jang Soo Yook Laboratory of Exercise Biochemistry and Neuroendocrinology, Faculty of Health and Sports Sciences, University of Tsukuba, Ibaraki, Japan, Center for Functional Connectomics, KIST Brain Research Institute, Korea Institute of Science and Technology 5,Seoul, Korea
  • Soo-Min Ha Laboratory of Exercise Physiology, Department of Physical Education, Pusan National University, Busan, Korea
  • You-Sin Kim Department of Sports Coaching, Jungwon university, Goesan, Korea
  • Do-Yeon Kim Laboratory of Exercise Physiology, Department of Physical Education, Pusan National University, Busan, Korea
  • Hideaki Soya Laboratory of Exercise Biochemistry and Neuroendocrinology, Faculty of Health and Sports Sciences, University of Tsukuba, Ibaraki, Japan, Department of Sports Neuroscience, Advanced Research Initiative for Human High Performance (ARIHHP), Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan

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