earticle

영어

The current study aims to investigate how mitochondrial dynamics and mitophagy are changed by a single bout aerobic exercise. Four month Fischer 344 rats were divided into 2 groups: sedentary group (SED, n=6) and acute exercise group (AEX, n=6). Rats were performed in a single bout treadmill exercise for 60 minutes. Mitochondrial fusion (e.g., Mfn1, Mfn2, Opa1), mitochondrial fission (e.g., Drp1, Fis1), and mitophagy (e.g., Parkin, Pink1, BNIP3, LC3) were measured in the permeabilized skeletal muscles (e.g., soleus, white gastrocnemius). Mitochondrial fusion-related protein (Opa1) was decreased in soleus of AEX compared with SED. Also, mitochondrial fission-related protein (Drp1) was reduced in soleus of AEX compared with SED. Similarly, in soleus muscle of AEX, mitochondrial autophagy-related protein (LC3) was decreased compared with SED. However, other proteins of mitochondrial dynamics and mitophagy didn’t show significant difference in soleus and white gastrocnemius. A single bout aerobic exercise showed tissue-specific results in mitochondrial dynamics and mitophagy. It demonstrates that acute aerobic exercise may improve mitochondrial function predominantly in soleus muscle (type I fiber). However, further research is needed to understand the cellular and molecular mechanism by which acute aerobic exercise affects mitochondrial dynamics and mitophagy in different types of muscle fibers.