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일반논문

유변학적 시험에 의한 연고제제의 물성평가

원문정보

Physical Characterization of Ointment by Rheological Methods

성학모, 도티 무이, 오주석

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

Purpose: Ointment type products are mainly viscous, semi-solid and high viscosity products such as vaseline and lanolin. If there is a large physical resistance during use, or if the material is aggregated or separated, it will not only lower the quality satisfaction but also reduce the stability of the product's efficacy. In this study, we conducted a study to confirm whether rheological test analysis is valid as a performance index of ointment. Method: 3 kinds of ointment containing vaseline were treated with electron beam at 0, 10, 15, 20, and 30 kGy. The viscoelastic properties (G′, G″, η*) were analyzed at 24 °C. and 0.1 rad/sec to 10.0 rad/sec using an ARS Rheometer P-200 (diameter 50 mm Fixture, Gap 1.0 mm). The sensory evaluation of the skin was also carried out, and the correlation with the rheological test results was analyzed. Results & Discuss: As a result of the rheological test of each composition according to the electron beam treatment, the deviation of test result in the sample was high, and when the physical force was applied, the partial separation of the components perhaps appeared to show the difference in physical properties. Also, G′(elasticity) of sample A decreased to 66%, while sample B increased to 158% as irradiation dose increased. And sample C decreased gradually up to 30%. G′and G″of each composition showed a non-Newtonian pattern with a gradual increase with increasing frequency but a decrease in viscosity. Specifically, G′values were 11.9%, 55.8% and 43.8% for samples(A, B and C) at the frequency of 0.1 rad/sec, and 36.4%, 23.4% and 8.3% for the 10.0 rad/sec appear. Sensory evaluation of each composition on the 5-point scale showed that the composition of A was 3.0, B was 3.15, and C was the highest at 4.35. The rheological evaluation condition that best corresponds to this scale is G′(10.0). This means that people prefer low elasticity products when measured at high frequencies. Conclusions: The rheometric method, which is a rheological property measurement method, is considered to be a valid method to measure the homogeneity of composition and the influence of electron beam treatment. When ointments are applied to human skin, it will show shear-thinning behavior at body temperature. Therefore, it will be meaningful to evaluate the rheological test at 37 ℃ in the future.

목차

Abstract
Ⅰ. 서론
1. 연고제의 일반적 특성
2. 연고제관련 물리적 인자
Ⅱ. 재료 및 방법
1. 연고제의 조제
2. 연고제의 전자빔멸균
3. 연고제의 유변학적 시험
4. 바름성에 대한 관능평가
Ⅲ. 결과 및 고찰
1. 전자빔 처리에 따른 각 조성의 유변학적 평가
2. 각 조성별 시료의 유변학적 물성평가
3. 각 조성별 유변학적 평가와 관능평가 사이의 비교
Ⅳ. 결론
Acknowledgement
References

저자정보

  • 성학모 Hark Mo Sung. (주)아크에이르
  • 도티 무이 Mui Do Thi. (주)아크에이르
  • 오주석 Ju Seok Oh. 한남대학교

참고문헌

자료제공 : 네이버학술정보

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