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Effect of Hydrogen and Oxygen Mixed Inhalation on Non-alcoholic Fatty Liver Disease

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Non-alcoholic fatty liver disease is closely related to insulin resistance and genetic susceptibility, and it is a metabolic stress liver injury. As a result of the multifactorial pathological development in vivo, endogenous reactive oxygen species (ROS) increase, leading to inflammatory necrosis of hepatocytes. In recent years, many studies have confirmed that hydrogen is not a physiological inert gas. It has reliable therapeutic properties for some diseases, such as type 2 diabetes, Parkinson's disease, atherosclerosis and so on. It can be said that hydrogen is a gas with great potential medical value. We used nitrogen-oxygen mixture as control, and inhaled hydrogen-oxygen mixture (66% hydrogen and 33% oxygen) to non-alcoholic fatty liver patients. We found that hydrogen can improve the blood lipid level, reduce the plasma total cholesterol level and low density lipoprotein level, and increase the liver/spleen CT ratio in patients with non-alcoholic fatty liver. At the same time, hydrogen can improve the anti-inflammatory and anti-oxygen ability of plasma in patients with non-alcoholic fatty liver. It can reduce plasma glutamic oxaloacetic transaminase and alanine transaminase levels in patients with nonalcoholic fatty liver disease. The results showed that hydrogen could protect hepatocytes and alleviate the degree of nonalcoholic fatty liver.

저자정보

  • Xue Yazhuo Shandong First Medical University (Shandong Academy of Medical Sciences), Shandong, China
  • Zhang Guangjie Shandong First Medical University (Shandong Academy of Medical Sciences), Shandong, China
  • Song Guohua Shandong First Medical University (Shandong Academy of Medical Sciences), Shandong, China
  • Qin Shucun Shandong First Medical University (Shandong Academy of Medical Sciences), Shandong, China

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