earticle

영어

Alcohol-induced hangover and liver diseases are considered as a cause of serious health morbidity, mortality and socio-economic burden worldwide. In recent years, many researchers explored abundant numbers of natural products related with hepatoprotective effect against oxidative damage. In this study we investigated the protective effects of urushiol-free enzyme-treated lacquer tree (Rhus verniciflua sap) extract (ELTE) on alcohol-induced in Sprague Dawley (SD) rat model. Rats were randomly divided into 3 groups; negative control without treatment (NeC), positive control group (PC) treated with anti-hangover drink (Condition), and experimental group orally treated with urushiol-free ELTE. Experimental materials were administered to each SD rat accordingly 25 mg/kg for 5 d via gavage. At 5th day after treatment of experimental materials, each group received a dose of ethanol (4 g/kg body weight) and blood serum sample was assessed after 1 h and 5 h to investigate immune-redox and hangover markers. Our results showed blood lymphocytes levels were significantly lower in ELTE group than NeC group. Likewise, ROS generation was significantly reduced in ELTE group as compared to all other groups. In line, alcohol concentration in blood was significantly reduced in PC and ELTE groups as compared with NeC group. Collectively, our results suggest that urushiol-free ELTE might be an excellent potential candidate against acute alcohol-induced hangover relief and liver protection.