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Purpose: The purpose of this study was to show the effects of voluntary change of weight bearing on the vastus medialis oblique and the vastus lateralis ratio during squat exercise. Methods: Twenty-four healthy adults were recruited for this study. The subjects performed squat exercise with median weight bearing, lateral weight bearing and non-changed weight bearing. The muscle activities of the vastus medialis oblique and the vastus lateralis were measured during the squat for all three conditions. The measured data were analyzed using one-way ANOVA to investigate the effect of muscle activation on the each condition. The statistical analyses were performed using SPSS ver. 17.0, and a p-value of less than 0.05 was considered significant for all cases. A post-hoc test was performed using Tukey’s test. Results: The study showed that the vastus medialis oblique and the vastus lateralis ratio significantly changed according to the voluntary change of weight bearing during a squat. The vastus medialis oblique and the vastus lateralis ratio significantly decreased under the condition of voluntary lateral weight bearing. Conclusion: We suggest squat exercise on median weight bearing to increase the vastus medialis oblique and the vastus lateralis ratio. If your patient has.