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영어

In this study, we investigated the effect of hops extract on inhibition of tyrosinase activity and collagen production and MMP-1 expression in human fibroblasts using M-tyrosinase and C-tyrosinase, Cytotoxicity and collagen production and MMP-1 expression were measured. The results showed that M-tyrosinase and C-tyrosinase significantly inhibited the activity of tyrosinase. Cell viability and cytotoxicity of HDF cells showed cytotoxicity at the concentrations of 6.25, 12.5 and 25 μg/ml of hops extract I did. Inhibition of MMP-1 activity was found to be insignificant and the effect of collagen synthesis was increased in a concentration-dependent manner. However, ascorbic acid As a positive control group, it was confirmed that the hops extract did not significantly affect the collagen production. Therefore, the anti-aging effect of the hops extract is considered to be insignificant.