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영어

This research has been conducted to explore the effect of Adenophora Radix, as a natural substance, on hair growth and to provide basic data on the development potential of Adenophora Radix as a cosmetic product for preventing hair loss. Accordingly a hair growth efficiency test and a clinical test on application to human skin were carried out through a mouse model. In relation to the hair growth efficiency test which was carried out through the mouse model, 6 weeks old C57BL/6 male mice were used as the test animal and a powder obtained from enrichment and lyophilization of a filtrate of adenophora triphylla var. japonica soaked in 70% ethanol liquid was used for the Adenophora Radix sample. As test substances, AR-1(1% Adenophora Radix extract), AR-2(5% Adenophora Radix extract), ethanol and PBS were used. Observations were carried out change on fractography of hair follicle, degree of melanin pigmentation. As a result of microscopic examination on test animal groups, the highest number of follicles and hair shaft in the follicles were shown in the group which AR-2 was applied. Higher number of follicles were shown in the following order AR-2>AR-1>ET>PBS. In relation to the degree of melanin pigmentation of skin, an observation was carried out on the 1st, 5th and 9th day and the value obtained on the 9th day was 267.15(±15.03), 320.45(±75.53), 320.45(±41.94), 193.10(±22.61) respectively according to each test group(p<0.05). C57BL/6 shows that melanocyte only exists restrictively in follicles and allows to determine the growth period of hair by skin colour since melanin synthesis confirms well with the hair growth period and shows a dark grey color during the growth period.