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Poster Presentation : Gene Expression / Function

Distinct Roles of Cep192 and Cep152 in Acentriolar MTOC and Spindle Formation in Mouse Oocytes

원문정보

In-Won Lee, Yu-Jin Jo, Seung-Min Jung, Yong-Han Kim, Nam-Hyung Kim, Suk Namgoong

한국동물생명공학회(구 한국동물번식학회) Reproductive & Developmental Biology(Supplement) Volume 41 No 2 Supplement 2017.06 pp.55-55
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Mammalian oocytes lack a centriole that acts as a microtubule organization center (MTOC) in most somatic cells. During oocyte maturation, MTOCs undergo remodeling process including decondensation, fragmentation and self-organization. But the underlined mechanisms of MTOC remodeling in mouse oocyte are not well understood. We showed that two pericentriolar proteins, Cep192 and Cep152 play crucial roles of MTOC remodeling. Cep192 is present in MTOC at all stages of oocyte maturation, and the depletion of Cep192 induces ablation of MTOC, delay inspindle formation and abnormal chromosomal alignment in spindles. In the case of Cep152, Cep152 localization of MTOC is limited at the germinal vesicle (GV) stage and then disappeare from the MTOC after germinal vesicle breakdown (GVBD). Cep152 exclusion from MTOC is involved in the fragmentation of MTOC and it is regulated by CDK1 activity. Together, our results demonstrate the different roles of Cep192 and Cep152 in MTOC remodeling and novel regulatory mechanism during meiotic spindle formation in mouse oocyte.

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저자정보

  • In-Won Lee Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea
  • Yu-Jin Jo Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea
  • Seung-Min Jung Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea
  • Yong-Han Kim Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea
  • Nam-Hyung Kim Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea
  • Suk Namgoong Department of Animal Sciences, Chungbuk National University, Brain Korea 21 Center for Bio-Resource Development, Chungbuk National University, South Korea

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자료제공 : 네이버학술정보

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