earticle

영어

Graphene oxide (GO) is a novel material derived from two-dimentional carbon lattice of graphene and has attracted increasing interest in the field of biomedicine as grug delivery, gene delivery, biosensers. Also G.O is well known that low toxicity in cells but effect in germ cell development are poorly understood. Leydig cells and Sertoli cells are somatic cells that surpport germ cells during spermatogenesis. In this study, we found that toxicity to leydig and sertoli cell line induced by G.O following variants size. The small size (about 27 nm) showing more high toxicity and cell damage, apoptosis in those somatic cells compare with large size (about 80 nm). Small size G.O is more easy to upkate to cells and effect to cells. Taken together, our study reveals that G.O showing cell toxicity, even if low, and possibility that interrupt spermatogenesis by damage of leydig and sertoli cells. It is important information that apply small size of G.O as biomeical drug.