earticle

영어

Silver nanoparticles (AgNPs) is one of the nanomaterials as most popular and commonly used in consumer products in biomedical devices, antibiotic agent, wound dressings, text tile and also candidate of anti-cancer material. F9 cell, the teratocarcinoma stem cell line has been widely used as a model for the analysis of molecular mechanisms associated with differentiation and retinoic acid (R.A) is well known molecule that induce F9 cell differentiation. There are many study about induce differentiation in stem cells by AgNPs and in anti-cancer therapy, induce cancer stem cell differentiation is very important to killing cancer. In this study, we demonstrated that AgNPs showing toxicity in F9 cells as anti-cancer cell effect and also induce F9 cell differentiation. F9 cells are induce cell toxicity and apoptosis after treated AgNPs and also make F9 cell differentiation like induced by R.A. Signaling pathway analysis showing that gene and protein expression going different and more sensetive to anti cancer drug, cisplatin, after induced differentiation by AgNPs. We found that potential of AgNPs as not only killing cancer but also make cancer stem cell going to differentiation.