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Poster Presentation : Gene Expression / Function

Integrated Transcriptomes throughout Swine Oestrous Cycle Reveal Dynamic Changes in Reproductive Tissues Interacting Networks

원문정보

Jun-Mo Kim, Jong-Eun Park, Inkyu Yoo, Jisoo Han, Namshin Kim, Won-Jun Lim, Eun-Seok Cho, Bonghwan Choi, Sunho Choi, Tae-Hun Kim, Marinus F. W. te Pas, Hakhyun Ka, Kyung-Tai Lee

한국동물생명공학회(구 한국동물번식학회) 발생공학 국제심포지엄 및 학술대회 2018년 한국동물번식학회, 한국수정란이식학회 공동학술대회 2018.06 pp.52-52
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Female fertility is a highly regulated process involving the synchronized activities of multiple tissues. The underlying genomic regulation of the tissue synchronization is poorly understood. To understand this better we investigated the transcriptomes of the porcine ovary, endometrium, and oviduct at days 0, 3, 6, 9, 12, 15, or 18 of the oestrous cycle. We analysed the transcriptome profiles of the individual tissues and focus on the bridging genes shared by two or more tissues. The three tissue-networks were connected forming a triangular shape. We identified 65 bridging genes with a high level of connectivity to all other genes in the network. The expression levels showed negative correlations between the ovary and the other two tissues, and low correlations between endometrium and oviduct. The main functional annotations involved biosynthesis of steroid hormones, cell-to-cell adhesion, and cell apoptosis, suggesting that regulation of steroid hormone synthesis and tissue viability are major regulatory mechanisms.

키워드

저자정보

  • Jun-Mo Kim National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Jong-Eun Park National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Inkyu Yoo National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Jisoo Han National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Namshin Kim National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Won-Jun Lim National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Eun-Seok Cho National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Bonghwan Choi National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Sunho Choi National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Tae-Hun Kim National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Marinus F. W. te Pas National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Hakhyun Ka National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research
  • Kyung-Tai Lee National Institute of Animal Science, Yonsei University, Chung-Ang University, Korea Research Institute of Bioscience and Biotechnology, Wageningen UR Livestock Research

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