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Role of Animal Models for Next Generation Assisted Reproductive Technology

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Since 1978 the world’s first baby was born by IVF, intracytoplasmic sperm injection (ICSI) using single sperm was developed in 1992. The assisted reproductive technology (ART) has been considered ultimate process for infertility caused by male or female factors. Especially, IVF with preimplantation genetic diagnosis (PGD) can prevent disease that may be inherited from the mother or father. Recently, mitochondrial (or nuclear) replacement techniques such as pronuclear transfer (PNT), maternal spindle transfer (MST) and polar body transfer (PBT) were developed between oocytes or zygotes for preventing mitochondrial disease carrying pathogenic mtDNA or improving oocyte quality. However, animal models are mostly non-human primates, such as monkeys and mice, and are not suitable for animal models that can represent the human reproductive system and life style. I hereby introduce ST and PBT as an assisted reproductive technique using micromanipulation, and would like to ask what animal models are appropriate for these research.

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  • 강은주 울산대학교

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