earticle

영어

Even human genome has been sequenced completely, we have very limited idea of all characterized genes at the protein level. Therefore, several attempts have been taken to map proteome of human chromosome. Since sex chromosomes determined the sex of individual, it important to study sex chromosome-encoded proteins. Here, we studied human sex chromosome- encoded proteins of the immune system, protein pathways, protein-protein interactions, and diseases association using several bioinformatics tools. We retrieved 30 proteins (X chromosome 28; Y chromosome 7; both 5) from the recent NCBI human genome annotation, based on their association with immune systems (immunological and inflammation pathways) by Pathway studio program. Searching of these proteins in the Human Proteome Project, including neXtProt, PeptideAtlas, and the Human Protein Atlas showed that all proteins were also identified in several cells and tissues of body. Proteins were further investigated using Pathway Studio and STRING programs. Pathway Studio and STRING programs showed 15 and 25 X chromosome-encoded proteins were interacted. All Y chromosome-encoded proteins showed interactions using STRING program, however no interaction was found using Pathway studio. In addition, difference in human sex chromosome-encoded proteins of the immune system showed an indirect relationship with the occurrence of some diseases in a sex specific manner.