earticle

영어

GWAS (Genome wide association study) strategy has been applied with the purpose to identity chromosomal regions and SNPs that control relevant traits. The development of SNP panel with the medium density (PorcineSNP60 BeadChip) allows the detection of QTL (Quantitative trait loci) and candidate genes near QTL with a higher resolution compared to using microsatellites in the past. The minimization of weaning to estrus interval (WEI) is the most economical trait in pigs due to a huge impact on the efficiency of pig production. Therefore, the aim of this study was to detect regions (1-Mb windows) and SNPs associated with weaning to estrus interval (WEI) for Yorkshire pigs. Reference population of 1,978 Yorkshire pigs were genotyped using Illumina PorcineSNP60 v2 SNP panel which were then imputed for missing genotypes with FImpute v2.2. BayesB with set to (0.99) method was used to identify the informative window regions and deregressed EPD and their reliabilities were used as a response variable and a weighting factor in GWAS model. In total, 6 genome regions explaining over 0.75% of the genetic variance and 6 SNPs were identified for WEI trait. A 1 Mb regions on chromosome 1 (SSC1), 4 (SSC4), 7 (SSC7) and 14 (SSC14), which showed strong evidence of linkage disequilibrium with QTL, explained from 0.75% to 1.52% for genetic variation for weaning to estrus interval trait. Our results suggested that it is feasible to improving the accuracy of the genomic selection by detecting the siginificant QTL regions for WEI trait.