earticle

영어

The uterus changes according to the estrous cycle and programmed cell death suitable for placenta formation plays a role in implantation and embryo formation. In the present study of this experiment was to understand the programmed cell death(PCD) for the estrus day 15 of uterus in normal and miniature pig. The our results there suevival associated-Gene(mTOR) expression was significantly higher from miniature pigs, but expression of genes related to cellular metabolic activity (IGF, PCNA) was mostly significantly higher in normal pig than the miniature pigs. Expression of the hormone receptor genes (FSH, LH) and 20a-HSD was higher in the normal pig than in the miniature pig. And gene expression of the progesterone receptor was lower in the normal pig. Expression of autophagy-related genes (ATG1, ATG5, ATG13, Beclin- 1) was significantly lower in the uterine tissues of the normal pig than in the miniature pigs, but the expression of the MAP1LC3A gene was significantly higher in the normal pig.There was non-differential in the expression of BAX gene related to apoptosis, but expression of casp-3 gene was significantly higher in normal pig uterine tissue. Our result is suggest that the uterus of normal pig on the 15th day to have high expression of genes involved in cell metabolism activity and cell reorganization as affected by LH hormone. The expression of the genes involved in cellular metabolism and cellular remodeling in the miniature pig uterus tissues seems to be low due to the activity of the progesterone hormone mechanism. The LH and FSH hormones been shown that induce cell expression and metabolic activity of the program cell daeth gene.