earticle

영어

Acute kidney injury (AKI) is one of the most devastating systemic condition that is interrelated with high mortility and morbidity rates. The majority of AKI in clinical practice is caused by ischemia reperfusion or neprotoxicity. The etiology and progression, as well as the mechanism of its resolution and recovery have been continuously studies using rodent models. However, it is of critical importance to evaluate this model in non-murine species to better translate the results from animal studies to clinical studies. Not only for sole AKI, renal Ischemia reperfusion warm injury occurs during donor kidney acquisition in transplantation. Therefore, AKI modeling in large animals, e.g., nonhuman primates, would benefit the understanding its pathophysiology and also maintain the graft function post-transplantation. We established a renal warm ischemia reperfusion model in cynomolgus monkeys, and determined several key evaluation parameters including serum biochemistry and histology works. This presentation will cover the brief story of both how our nonhuman primate research facility was setup, and also several key findings from our monkey experiments.