earticle

영어

Among the animal, human uniquely contains high amount and diverse structure of soluble oligosaccharides in milk. The multiple functions for infant of human milk oligosaccharides (HMOs) have been well discussed, particularly sialic acid and fucose containing oligosaccharide. The structure and composition of HMOs structure were diverse among different mothers or breastfeeding period of a given woman as well, and nutritional conditions. The geographical origin of mothers is one of the factors that influence on the HMOs diversity. Hence, we aim to profile HMOs from mothers in Korea, China and Vietnam in the relation to their nutritional status to provide a comprehensive understanding about HMOs from maternal in these countries. The results show that oligosaccharide composition of human milk varied among countries. HMOs from Korea and China were almost similar in term of degree of polymerization (DP) whereas Vietnam HMOs has lower DP3 but high in DP4 and DP5. The ratio of non-secretor mothers that were unable to produce α-1, 2-fucosylated glycans in their secretions, following by Vietnam and lowest in Korea population. The fucosylated, and sialylated HMOs were 62-67%, 4-6% in China and Korea milk respectively while 50% and 9.2% in Vietnam maternal milk. These observed proportion were different from earlier studies that may due to the difference in geographical origin of mothers. Elucidating molecular structure of HMOs provides an important opportunities for improving diet and health care for the neonate in specific region.