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학생구두발표

Paracrine effects of human U937 macrophages on mini pig adipose tissue-derived mesenchymal stem cell differentiation: the possibility of NM23-H1 as a ganglioside GD3 suppressor

원문정보

Sung Youn Heo, You Na Seo, Won Seok Ju, Hyun Gyu Lim, Sang-Young Seo, Jin Hyoung Cho, Park Soon Ju, Young-Kug Choo

한국당과학회 한국당과학회 학술대회 2018 한국당과학회 동계학술대회 2018.01 pp.70-70
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Mesenchymal stem cells are undifferentiated stem cells that can differentiate into various cells and tissues. In this study, we confirmed the difference in expression and differentiation rate of gangliosides during the differentiation of mini-pig adipose-derived mesenchymal stem cells into neuronal cells using secretion medium from PMA-induced human macrophage-like cell line U937 (Macro SM). We showed that nm23, one of several proteins secreted in the culture medium of activated human macrophages, decreased the neuronal differentiation rate of mesenchymal stem cells derived from mini-pig adipose, and inhibited the function and the synthesis enzyme of GD3. In conclusion, one of the factors that decreased the differentiation rate of mini-pig adipose-derived mesenchymal stem cells into neuronal cells by Macro SM is the nm23 protein.

저자정보

  • Sung Youn Heo Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea
  • You Na Seo Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea
  • Won Seok Ju Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea
  • Hyun Gyu Lim Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea
  • Sang-Young Seo Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea
  • Jin Hyoung Cho Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea Institute for glycoscience, Wonkwang University, Iksan, Jeonbuk 54538, Korea
  • Park Soon Ju Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea
  • Young-Kug Choo Department of Biological Science, College of Natural Sciences, Wonkwang University, Iksan, Jeonbuk 54538, Korea Institute for glycoscience, Wonkwang University, Iksan, Jeonbuk 54538, Korea

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