원문정보
초록
영어
O-GlcNAcylation is a carbohydrate post-translational sugar modification occurs on hydroxyl groups of serine or threonine residues of cytosolic and nuclear proteins. It is known that O-GlcNAc addition and removal regulate many biological events like transcription, protein degradation, proliferation. Epithelial-mesenchymal transition(EMT) is a process that epithelial cells lose its polarity and cell-cell contact, therefore get migratory capabilities to become mesenchymal stem cells. There are several reports that O-GlcNAc is associated with cancer EMT and metastasis. But there are still much to discover the role of O-GlcNAc on TGF-β-induced EMT. TGF-β is one of the powerful EMT inducer, and is primarily dependent on TGF-β/Smad signaling pathway. Here we found that Smad protein expression is regulated by global O-GlcNAc change, consequentially controls TGF-β-induced EMT. Now we’re planning to verify how O-GlcNAc controls Smad expression.