earticle

영어

Rhamnose is naturally occurring deoxy-sugar commonly bound to other sugars in nature. It is a common glycogenic component of glycosides in many plants and microbes. Indigenously available TDP-L-rhamnose from E. coli can be conjugated to natural products using specific glycosyltransferases. Current research focus on the enhancement in production of such potential anthraquinone deoxy-sugar conjugated products through microbial engineering and biotransformation approach. A recombinant E. coli strain was designed by expressing rhamnosyltransferase and anthraquinones were fed exogenously to produce several anthraquionone rhamnose-conjugated derivatives. Among all anthraquinones; Quinizarin, 1,4-dihydroxy-9,10-anthraquinone was efficiently bio-transformed yielding high production. These anthraquinones have important applications in the field of medicine, such as inhibitory effects against human intestinal bacteria. In addition, quinizarin exhibits inhibitory effects in the aflatoxin B1 biotransformation to the corresponding 8, 9-epoxides, which is responsible for the toxic and carcinogenic effects of aflatoxins.