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Purpose: The aim of the research was to define the effects of body image, career identity, and family health on depression in college students. Methods: This descriptive research was conducted from the 1st to the 16th of July, 2018. The data was collected through convenience sampling of 222 college students. To draw conclusions from the data, we used statistical analysis of Pearson's correlation coefficients and stepwise multiple regression using SPSS/WIN 21.0. Results: Depression showed negative correlations with body image, career identity and family health. Multiple regression revealed that the factors significantly influencing depression were body image, career identity, and gender. The total explanation of depression by these variables was 29.9%. Conclusion: These findings indicate that intervention strategies to prevent and manage depression in college students should include programs to help them develop positive body image and career identity, considering gender differences.