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Objectives: The aim of this study was to examine factors influencing health-related quality of life of waged workers. Methods: This study used data from the Seventh Korea National Health and Nutrition Examination Survey. Data were analyzed with the χ2-test, t-test, ANOVA, and multiple regression. Results: The significant predictors of health-related quality of life were depression, subjective health status, age, activity limitation, education, worker status, monthly income, drinking, smoking, physical injury, stress, and moderate physical activity. Conclusions: Personal health characteristics, psychological characteristics, socioeconomic characetrictics and working characetrictics affect health-related quality of life. Health-related quality of life is also affected by social structural problems such as socioeconomic factors and employment instabilitye. In addition to the development of health care programs to improve health-related quality of life of twaged workers, policy changes are needed to improve the social structure.