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Objectives: This study aimed to examine the effects of compassion competence, professional self-concept and nursing practice environment on caring behaviors of clinical nurses. Methods: A convenience sample of 200 nurses was drawn from a tertiary hospital in G city. Structured self-report questionnaires were used to collect data, which were analyzed with descriptive statistics, t-test, ANOVA, Pearson’s correlation coefficient, and stepwise multiple regression. Results: A significant difference in caring behaviors of nurses was found for age, educational level, and unit. There were statistically significant positive correlations between study variables. Sensitivity and communication of compassion competence, communication of professional self-concept, and nursing foundations for quality of care in nursing practice environment were significant predictors of caring behaviors, explaining 51.3% of total variance. Conclusions: To improve clinical nurses’ caring behaviors, strategies must be developed and implemented for enhancing their compassion competence, professional self-concept, and nursing practice environment