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Original Article

The effectiveness of gabapentin and exercises in the treatment of carpal tunnel syndrome : a randomized clinical trial

원문정보

Omid Hesami, Mahsa Haghighatzadeh, Behnam Safarpour Lima, Naghmeh Emadi, Shahin Salehi

한국운동재활학회 JER Vol.14 No.6 2018.12 pp.1067-1073
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초록

영어

Carpal tunnel syndrome (CTS) is one of the reasons for labor abandon-ment due to inability and pain. The aim of this study was to evaluate the effectiveness of gabapentin and exercise training in the treatment of CTS and compare their effects. This single-blind clinical trial was con-ducted on patients referred to the Imam Hossein hospital’s electrodiag-nostic (EDX) unit. The patients randomly assigned into four groups: us-ing nocturnal splint as an approved treatment in the control group; tak-ing 300-mg gabapentin per night and using nocturnal splint; nerve and tendon gliding exercises and using nocturnal splint; and taking 300-mg gabapentin per night, performing same exercise as group 3 and using nocturnal splint. At baseline, four indicators were assessed in all pa-tients, including the Boston carpal tunnel questionnaire, visual ana-logue scale (VAS), pinch and grip strength of the affected hand. One month after the beginning of intervention, participants were reassessed and compared for each of the four indicators. Using nocturnal splint along with exercise and gabapentin significantly improved VAS, pinch and grip strength in moderate CTS compared to control group that only used nocturnal splint. However in mild CTS, grip strength was not sig-nificantly higher compared to control group (P=0.048). Results of this study showed that use of splint alone in mild CTS is an appropriate and sufficient treatment; however, in moderate CTS, receiving gabapentin along with exercise and splinting showed better treatment results com-pared to splinting alone.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Trial design
Inclusion criteria
Intervention
Randomization
Measurement
Self-report questionnaire
Performance-based outcome measures
Tendon gliding exercises
Nerve gliding exercise
Analysis
RESULTS
DISCUSSION
CONFLICT OF INTEREST
REFERENCES

저자정보

  • Omid Hesami Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran
  • Mahsa Haghighatzadeh Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran
  • Behnam Safarpour Lima Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran
  • Naghmeh Emadi Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Shahin Salehi Department of Sports Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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