earticle

영어

The epigenesis is a phenomenon in which genetic information is expressed differently due to inherited factors such as environment, habit, and virus infection without changing the gene base sequence itself. Although many researchers could reveal many secrets of life through deciphering the human genome sequence, many studies using epigenetic have been attempted because genome had difficulty in explaining the various disease incidence. Large-scale projects are being actively carried out globally, and Korea is also participating in this project. We investigated what kind of research was carried out internationally using the epigenome and analyzed the technical factors that are needed to start the study of the epigenetic genome in this paper. We investigated applicable research areas using these techniques and introduced one epigenome project that our team has actually done. Our study used integrated network between DNA methylation and expression, identify epigenetic regulating network hub genes associated with anti-asthmatic effects by D. sophia seed extract (DSE) treatment in OVA-induced mouse model. We hope that the results of this study will lead to the development of diverse epigenetic studies in the field of Korean medicine. 후성유전체 연구동향 분석 및 한의약 활용 방안 연구 김철 책임연구원* , 성보석 선임연구원, 장윤지 선임연구원 한국한의학연구원 미래의학부 Analysis of the epigenome research trends and study on utilization of Korean Medicine Chul Kim*, Seong Boseok, Jang Yunji Future Medicine Division, Korea Institute of Oriental Medicine Correspondence: Chul Kim Future Medicine Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea Tel: +82-42-868-9582, E-mail: chulnice@kiom.re.kr Received 2018-11-16, revised 2018-11-27, accepted 2018-11-28, available online 2018-12-01 doi:10.22674/KHMI-6-2-12 Keywords: epigenome, epigenetic research, trend analysis, technical