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Objectives: The purpose of this study was to identify the quality of life of a serious case and to analyze the factors influencing them. A serious disease were limited to cancer, cerebrovascular disease, and cardiovascular disease. Methods: This study used original data from the 6th National Health and Nutrition Survey (2013～2015) and finally extracted 385 persons diagnosed with cancer, cerebrovascular disease and cardiovascular disease among adults over 20 years old. Linear logistic regression analysis was conducted to identify factors affecting the quality of life of this study subjects. Results: The quality of life scores of the subjects were 13.92±1.54 points (Highest possible=15). Regression analysis showed that quality of life decreased as age increased, lower income level, lower education level, stress, depression, suicidal ideation. The explanatory power (R2) of the analysis model was 0.170. Conclusions: The results of this study showed that age, income level, education level, stress, depression, and suicidal ideation affect the quality of life of a serious case in the community.