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Objectives: This study aimed to analyze the association between adolescent depression and personal factors such as interpersonal relationship and personal characteristics. Methods: The data used for this study was taken from the 2014 Korean Children and Youth Panel Survey. Of those 2,351 subjects in a data set, data of 1,938 subjects were analyzed after excluding 413 subjects with missing information. Hierarchical regression analysis was conducted for multi-variate analysis. In addition, controlling effects of ego-resiliency was analyzed. SPSS 22.0. was utilized for statistical analyses. Results: The study found that the depressive index was higher in women than men, and lower in adolescent who has a good relationship with parents and friends. This study also found that adolescents with high ego-resiliency are more vulnerable to depression. Conclusions: It is recommended to understand and to utilize ego-resiliency of adolescents, in order to reduce adolescents depression. Promoting good relationship with parents and friends will also positively impact to lower adolescents depression.