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Original Article

Oral adenosine 5′-triphosphate supplementation improved hemodynamic and autonomic parameters after exercise in hypertensive women

초록

영어

The aim of this study was to verify the autonomic modulation and blood pressure after adenosine-5’-triphosphate (ATP) supplementation asso-ciated to acute aerobic exercise in hypertensive women. Eleven hyper-tensive women (age, 61.8±5.0 years) completed a randomized, double blind trial: ATP supplement condition (ATP=400 mg) or placebo. After 30 min of supplementation or placebo intake, the subjects performed 30 min of aerobic exercise (70%–75% of maximum heart rate). The auto-nomic modulation was assessed by heart rate variability during rest and recovery (postexercise until 30 min of recovery), the square root of the mean squared difference between adjacent RR intervals (RMSSD), standard deviation of successive values (SDNN), low frequency (LF) and high frequency (HF) were measured. The blood pressure (systolic blood pressure [SBP] and diastolic blood pressure, mmHg) were re-corded at rest, immediately postexercise, post-10, post-20, and post-30 min after exercise. For RMSSD, there was statistically significant differ-ence during recovery, with higher RMSSD for ATP compared to placebo (rest=16.4±8.5 vs. placebo=11.6±4.0; ATP=18.5±9.7 msec; P=0.020). When analyzing the delta (recovery minus rest), the RMSSD (ATP=2.1± 7.2 msec vs. placebo=-4.7±7.5 msec; P=0.009), LF (ATP=-19.8±122.7 vs. placebo=-94.1±200.2 msec2; P=0.02), and SDNN (ATP=-2.8±12.2 msec vs. placebo=-10.6±10.5 msec; P=0.010) were higher for ATP than placebo. Furthermore, there was a greater postexercise hypotension at 20 min for ATP (SBP: ATP=-13.2±8.4 mmHg vs. placebo=-6.1±9.9 mmHg; P=0.006). Acute ATP supplementation promoted greater postexercise hypotension for systolic blood pressure and induced faster recovery of heart rate variability in hypertensive women.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Experimental design
  Subjects
  Procedures
  Blood pressure and autonomic modulation measurements
  Exercise protocol
  Statistical analysis
 RESULTS
 DISCUSSION
 CONFLICT OF INTEREST
 REFERENCES

저자정보

  • Marcelo Conrado de Freitas Skeletal Muscle Assessment Laboratory (LABSIM), São Paulo State University (UNESP), School of Technology and Sciences, Department of Physical Education, Presidente Prudente, Brazil, Department of Nutrition, São Paulo Western University-UNOESTE, Presidente Prudente, Brazil
  • Ana Laura Ricci-Vitor Department of Physiotherapy, São Paulo State University (UNESP), Presidente Prudente, Brazil
  • Renan Valero Freire Skeletal Muscle Assessment Laboratory (LABSIM), São Paulo State University (UNESP), School of Technology and Sciences, Department of Physical Education, Presidente Prudente, Brazil
  • Erico Chagas Caperuto University São Judas Tadeu, São Paulo, Brazil
  • Luiz Carlos Marques Vanderlei Department of Physiotherapy, São Paulo State University (UNESP), Presidente Prudente, Brazil
  • Fábio Santos Lira Exercise and Immunometabolism Research Group, Department of Physical Education, São Paulo State University (UNESP), Presidente Prudente, Brazil
  • Fabrício Eduardo Rossi Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, Federal University of Piauí (UFPI), Teresina, Brazil

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