Review Article

The combined impacts of docosahexaenoic acid, endurance physical exercise, and prolonged fasting on brain function


Yi-Sub Kwak, Sun Young Lim

한국운동재활학회 JER Vol.14 No.4 2018.08 pp.540-544
피인용수 : 0(자료제공 : 네이버학술정보)



Docosahexaenoic acid (DHA), a long chain polyunsaturated fatty acid (PUFA) is highly enriched in the membrane phospholipids of the brain, neuronal tissue and retina. Accumulating evidence suggests that brain DHA is necessary for maintaining for optimal function of the cognition and the visual system, particularly the photoreceptor, the retina. Loss of brain DHA, especially during crucial brain development period, was highly associated with visual and cognitive defects. Here it would be addressed the effect of DHA on brain functions as assessed by spatial task performance using a first generation model which is similar to hu-man nutrition case. And also, it was well known that prolonged fasting and energy restriction with endurance physical exercise stimulate cog-nitive function and brain function, which is caused by upregulated ke-tone body and upregulated brain-derived neurotropic factor (BDNF) re-sponses. In the DHA intake or prolonged physical exercise, upregulated BDNF can activate mitochondrial biogenesis to elevate neuronal bioen-ergetics and enable synaptic formation. And it also can activate DNA repair in neurons. Further study on the mechanisms about the combine effects of supplementation of DHA and energy restriction on brain func-tion is urgently needed in this area.




  • Yi-Sub Kwak Department of Physical Education, College of Arts, Design and Sports Science, Dong-Eui University, Busan, Korea
  • Sun Young Lim Division of Marine Bioscience, Korea Maritime and Ocean University, Busan, Korea


자료제공 : 네이버학술정보

    함께 이용한 논문

      ※ 기관로그인 시 무료 이용이 가능합니다.
      ※ 학술발표대회집, 워크숍 자료집 중 4페이지 이내 논문은 '요약'만 제공되는 경우가 있으니, 구매 전에 간행물명, 페이지 수 확인 부탁 드립니다.

      • 4,000원

      0개의 논문이 장바구니에 담겼습니다.