earticle

영어

Obesity is a risk factor able to trigger several inflammatory alterations and the imbalance between pro- and anti-inflammatory cytokine pro-ductions. Physical exercise is an important strategy for reduction of in-flammatory established process. The aim of this study was to evaluate the effect of 16 weeks of three exercise training programs in the inflam-matory profile and insulin resistance in overweight/obesity. Thirty two men and women (46.4±10.1 years; 162.0±9.1 cm; 82.0±13.6 kg) were divided into three groups for training on a treadmill: continuous at 70% maximum heart rate (HRmax) 5 times a week (CONT); 1×4 min (1-bout) and 4×4 min (high intensity interval training, HIIT) at 90% HRmax 3 times a week. Interleukin (IL) 6 and IL-10, tumor necrosis factor-alpha (TNF-α), insulin and adiponectin levels were analyzed by enzyme-linked immu-nosorbent assay, and homeostasis model assessment insulin resis-tance was calculated. After 16 weeks of training blood concentrations of IL-6 decreased in the HIIT group (P=0.035), TNF-α decreased in the CONT (P=0.037) and increased in HIIT (P=0.001) and adiponectin de-creased in the three training models. There was a trend towards de-creased body weight and body mass index (BMI) after HIIT only (P=0.059 and P=0.060, respectively). Despite the decrease of adi-ponectin and the increase of TNF-α in HIIT group, insulin sensitivity showed a trend for improvement (P=0.08). HIIT program decreased IL-6 at rest and although not significant was the only who tended to de-crease total body weight and BMI. Taken together, our data suggest that both HIIT as well as CONT exercises training program promotes changes in inflammatory profile in overweight/obesity, but dissimilar re-sponse is seen in TNF-α levels.