Antidepressants are drugs that relieve symptoms of depressive disor-ders. Fluoxetine, tianeptine, and milnacipran are different types of anti-depressants, and they have widely been used for relieving of depres-sion symptoms. In the present study, the effects of fluoxetine, tianeptine, and milnacipran on the glycine-induced ion current by nystatin-perfo-rated patch clamp and on the amplitude of field potential in the hippo-campal CA1 region by multichannel extracellular recording, MED64, system, were studied. In the present results, fluoxetine, tianeptine, and milnacipran reduced glycine-induced ion current in the hippocampal CA1 neurons in nystatin-perforated patch clamp method. These drugs enhanced the amplitude of the field potential in the hippocampal CA1 region in MED64 system. These results suggest that antidepressants may increase neuronal activity by enhancing field potential through in-hibition on glycine-induced ion current.
MATERIALS AND METHODS
Patch clamp recording
MED64 system recording
Effects of antidepressants on glycine-induced ion current in rat hippocampal CA1 neurons
Effect of glycine on antidepressants-induced field potential in rat hippocampal slices
CONFLICT OF INTEREST