원문정보
초록
영어
Maternal infection is an important factor causing neonatal brain injury and later developmental disability. In the present study, we investigated the effects of treadmill exercise intensity on short-term memory, hippo-campal neurogenesis, and expression of brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor B (TrkB) in the rats born of lipopolysaccharide (LPS)-exposed maternal rats. The rats were divided into six groups: control group, mild-intensity exercise group, moder-ate-intensity exercise group, maternal LPS-exposed group, maternal LPS-exposed and mild-intensity exercise group, maternal LPS-exposed and moderate-intensity exercise group. The rats in the exercise groups were forced to run on a treadmill for 30 min 5 times a week for 4 weeks. The exercise load consisted of running at the speed of 8 m/min for the mild-intensity exercise groups and 14 m/min for moderate-intensity ex-ercise groups. The latency in the step-down avoidance task was deter-mined for the short-term memory. Immunohistochemistry for 5-bro-mo-2’-deoxyuridine was performed to determine hippocampal cell pro-liferation and neurogenesis. Western blot analysis was performed for the detection of BDNF and TrkB expression. In the present study, tread-mill exercise improved short-term memory deteriorated by maternal LPS exposure. Treadmill exercise increased cell proliferation and neu-rogenesis in the hippocampal dentate gyrus of the rats born of the LPS-exposed maternal rats. Treadmill exercise increased BDNF and TrkB expression in the hippocampus of the rats born of the LPS-ex-posed maternal rats. These effects of treadmill exercise were similarly appeared at both mild-intensity and moderate-intensity.
목차
INTRODUCTION
MATERIALS AND METHODS
Animals and treatments
Exercise protocol
Step-down avoidance task
Tissue preparation
BrdU immunohistochemistry
Western blot analysis
Data analysis
RESULTS
Effect of treadmill exercise on the short-term memory
Effect of treadmill exercise on the cell proliferation and cell survival in the hippocampal dentate gyrus
Effect of treadmill exercise on the expressions of BDNF and TrkB in the hippocampus
DISCUSSION
CONFLIC OF INTEREST
ACKNOWLEDGMENTS
REFERENCES