earticle

영어

Nitric oxide (NO) is one of major inflammatory mediators which can provoke inflammatory reactions to infections. It is well known that excessive production ofNO is implicated in the pathogenesis of many diseases such as atherosclerosis, neurodegenerative diseases, inflammatory autoimmune diseases, and cancer. Gardeniae Fructus (the matured fruit of Gardeniajasminoides) is traditionally used to treat inflammation in East Asia including Korea, China, and Japan. In the present study, Gardeniae Fructus water extract (GFW) at concentrations of 10, 25, 50, 100, and 200ug/mL increased the cell viability of mouse macrophages RAW 264.7 and reduced NO production ofRAW 264.7 significantly (P<0.05). And GFW at concentrations of I 0, 25, 50, 100, and 200ug/mL significantly inhibited LPS-induced production of NO in RAW 264.7 (P<0.05). These results mean that GFW might have anti-inflammatory activity concerned with modulation of NO production in immune reaction. Further detailed studies deserve to elucidate the exact mechanism of anti-inflammatory activity of GFW in macropahges.