원문정보
초록
영어
Psoriasis is an auto-inflammatory disease that is prevalent throughout all age and ethical groups. This research was conducted to investigate possible uses of bacteria to condition the inadequate balance in a psoriatic patient’s skin. There were three primary parts to this research, which were to collect bacteria from psoriatic patients and normal subjects, classify the collected bacteria based on distinguishing characteristics, and finally initiate an antibiotic effect between these skin bacteria. A total of eight bacteria were selected in this research. Each of these bacteria were cultivated in each of the broth media containing the bacterial extracts in all possible combinations, producing an antibiotic effect. While the normal skin had an abundance of acidophilic bacteria and a lack of general bacteria, abnormal psoriatic skin had more general bacteria than acidophilic bacteria, displaying the inadequacy of dermal balance in the skin of psoriatic patients. In the antibiotic effect, two bacteria ‘Dp’ and Gn’ which were found in normal skin, were determined to suppress the growth of a bacteria only found in a psoriatic patient’s psoriatic site. Therefore, by using the effective aspects of these bacteria, a clinical application would be possible in controlling the unbalance of skin condition in psoriatic patients.
목차
1. INTRODUCTION
2. MATERIALS AND METHODS
2.1. Making Bacterial Culture Media
2.2. Collecting Psoriatic Patients' Skin Bacteria and Normal Skin Bacteria
2.3. Cultivating Skin Bacteria in Culture Media
2.4. Classifying the Cultivated Bacteria
2.5. Making Pure Culture and Reinvestigating Data
2.6. Antibiotic Effect of Skin Bacterial Extract - Formulating Bacterial Combinations
2.7. Antibiotic Effect of Skin Bacterial Extract - Assessing Constants and Variables
2.8. Antibiotic Effect of Skin Bacterial Extract - Evaluating Number of Bacteria
2.9. Antibiotic Effect of Skin Bacterial Extract - Analyzing Antibiotic Effect Data
2.10. DNA Observation (BlastN Analysis) & Clinical Application
3. RESULTS AND DISCUSSION
3.1. Classified Bacteria Chart Analysis
3.2. Distinguished Bacteria Chart & pH Analysis
3.3. Antibiotic Effect Analysis Part One
3.4. Antibiotic Effect Analysis Part Two
4. CONCLUSION
5. ACKNOWLEDGEMENTS
6. REFERENCES