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P.oleracea, commonly known as a pigweed, is reported as a plant that lowers cholesterol increased by high-fat diet, is effective to improve the liver function (Won et al., 2011), activates antiobesity cell (Lee et al., 2006), and is effective to decrease the obesity cell. This research was aimed to observe antioxidative and antibacterial effect of P.oleracea on pathogenic bacteria and to study its antiobesity effect on mice. P.oleracea was extracted in two different ways-organic solvent and hot water-, and then liquefied culture and agar diffusion method were done on 6 types of bacteria-Bacillus cereus, Escherichia coli, Lactobacillus delbrueckii subsp. Bulgaricus, Staphylococcus aureus, Streptococcus thermophilus, Vibroparahaemolyticus- in order to check its antibacterial effect. Moreover, after P.oleracea extract, sugar solution, or the mixture of the two was provided to mice and their weight increase were checked, and through dissection afterward, their change in immunity was observed. Antioxidative ability was tested through the oxidation of iron and DPPH radical scavenging activity. As a result, P.oleracea showed antibacterial activity over 70% on 5 types of bacteria except E.coli, and mice that P.oleracea extract was provided with sugar had similar rate of weight increase to the control group. While weights of liver and kidney of mice in sugar provided group were heavier than the control group, P.oleracea extract provided group had similar weight to the control group, which shows that the extract help metabolism. Moreover, its antioxidative ability was confirmed by improving the oxidation of iron and DPPH radical scavenging activity. Conclusively, P.oleracea has high antibacterial activity on pathogenic bacteria, prevents from obesity caused by sugar, and has outstanding antioxidative effect.