원문정보
초록
영어
KiSS1-derived peptide receptor, a GPCR protein, binds with the hormone Kisspeptin plays a major role in the neuroendocrine regulation of reproduction. It is important in the onset of puberty and triggers the release of gonadotrophinreleasing hormone. It is a potential drug target for the disorders related to GnRH, hence, analysing the structural features of the receptor becomes important. The three dimensional of the receptor modelled in a previous study was utilised. In this study, we have analysed the protein – protein interaction of the receptor with Kisspeptin 10 and 15. The study revealed the important residues which are involved in the interaction. The result of this study could be helpful in understanding the mechanism of Kiss1 receptor activation and the pathophysiology of the disorders related to the receptor.
목차
1. Introduction
2. Material and Methods
2.1. Homology Modelling
2.2. Protein-Protein Docking
3. Results and Discussion
3.1. Peptide Structure Prediction
3.2. Protein-Protein Docking
4. Conclusion
References