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Original Article

Effects of exercise on sexual function and central mechanism in the streptozotocin-induced diabetic rats

원문정보

초록

영어

Diabetes mellitus is associated with the impairment of sexual function including desire and orgasmic dysfunction. Sexual dysfunction in the diabetes mellitus is due to a selective defect of the nitric oxide synthase (NOS) within paraventricular nucleus (PVN). c-Fos is an immediate ear-ly gene and c-Fos expression represents neuronal activity in response to various stimuli. In the present study, we investigated the effects of treadmill exercise on sexual behaviors and the expressions of NOS and c-Fos in the PVN were evaluated using streptozotocin (STZ)-induced diabetic rats. Diabetes mellitus was induced by intraperitoneal injection of STZ. The rats in the treadmill exercise groups were made to run on a treadmill for 30 min once a day during 4 weeks. Male sexual behaviors were evaluated by recording the number of mounting, intromission, and ejaculation frequency. The present results revealed that treadmill exer-cise ameliorated sexual dysfunction in the STZ-induced diabetic rats. Treadmill exercise restored the contents of NOS and c-Fos in the PVN. The improving effect of treadmill exercise on sexual function can be considered as the neuronal activating effect of exercise through in-creasing expressions of NO and c-Fos.

목차

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and treatments
  Treadmill exercise protocol
  Sexual behavior test
  NAPDH-d histochemistry
  Immunohistochemistry
  Data analysis
 RESULTS
  Sexual behavior test
  NADPH-d-positive cells in the hypothalamic PVN
  nNOS expression in the hypothalamic PVN
  c-Fos expression in the hypothalamic PVN
 DISCUSSION
 CONFLICT OF INEREST
 ACKNOWLEDGMENTS
 REFERENCES

저자정보

  • Jae-Min Lee Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
  • Tae-Woon Kim Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
  • Hye-Sang Park Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
  • Sang-Seo Park Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
  • Mal-Soon Shin School of Global Sport Studies, Korea University, Sejong, Korea
  • Yun-Hee Sung Department of Physical Therapy, Kyungnam University, Changwon, Korea
  • Tae-Beom Seo Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea
  • Young-Pyo Kim Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea

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