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Purpose: The purpose of this study is to evaluate the trueness and fitness of machined prostheses according to drill radius setting in CAD software. Methods: For this study, standard abutment were replicated in Type Ⅳ stone. The stone abutment were scanned using a dental scanner. The CAD design software was designed using scanned abutment data. When designing, the drill radius was set to 0.3 mm and 0 mm, respectively, and saved. The saved design data was milled using a milling machine (n=13). The inner surface of the milled crown was scanned. The trueness and fitness were measured using the inner scan data of prostheses. Independent t-tests were performed to identify significant differences in each data. Results: Trueness values of the data saved with 0.3 mm and 0 mm drill radius were 18.9 ±2.3 ㎛ and 19.1 ±0.9 ㎛, respectively. There was no statistically significant difference between the groups. Fitness values of the data saved with 0.3 mm and 0 mm drill radius were 65.5 ±0.8 ㎛ and 33.8 ±1.0 ㎛, respectively. There was a statistically significant difference between the groups (p<.05). Conclusion : Setting the drill radius is important to produce clinically good fit prostheses.