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Purpose: This is a qualitative descriptive study with the purpose of identifyng the health problems and related factors of socially vulnerable school-age children in Seoul, South Korea. Methods: Two focus group interviews and two individual interviews were conducted with eleven participants. They were two class teachers, three school nurses and two daycare teachers working at elementary schools and three social workers and a welfare worker working at community childcare centers. Data were analyzed using qualitative content analysis. Results: The identified psychosocial problems were ‘distracting and excessive behavior’, ‘depression and helplessness,’ ‘aggression and violent behaviors’, and ‘internet overdependence’. The revealed physical health problems were ‘poor hygiene’, ‘obesity’, and ‘gastrointestinal problems’. In addition, the fact that physical and psychosocial problems are closely inter-linked was reaffirmed through practical examples. Meanwhile, socioeconomic, family environmental, social experiential and individual factors were found to affect children’s health. Relationships within a family or a peer group and healthy lifestyle were considered critical issues to deal with in order to improve the childrens’ health status. Conclusions: It was proved that socially vulnerable school-age children have various physical and mental health problems due to multiple factors. Therefore, it is required to design nursing approaches that help them achieve optimal health status.