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Expression Patterns of TGF- β 1, TGF- β Receptor Type I , II and Substrate Proteins Smad 2, 3, 4 and 7 in Bovine Oocytes and Embryos

원문정보

Hak-Jae Chung, Bong-Ki Kim, Jong-Mu Kim, Hyun-Gi Lee, Joo-Hee Han, Nam-Hyung Kim, Jin-Ki Park, Hwan-Hoo Seong, Boh Suk Yang, Won-Kyong Chang, Yeoung Gyu Ko

한국동물생명공학회(구 한국동물번식학회) Reproductive & developmental biology Volume 30 No 4 2006.12 pp.271-277
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초록

영어

Transforming growth factor-β (TGF-β) has been shown to have a positive effect on in vitro fertilization (IVF) and has been reported to stimulate meiosis at follicular level in variety of species. The study was designed to determine the expression patterns of TGF-β1, TGF-β receptors type Ⅰ, Ⅱ and Smads gene in bovine oocytes and embryos. TGF-β1 and their receptors were observed in the unfertilized oocytes. TGF-β1 and type Ⅱ receptor were not expressed at the blastocyst stage, however, only type I receptor was exclusively observed at the same stage. The blastocyst stage, in particular, showed high levels of mRNA expression patterns containing a TGF-β type Ⅰ receptor. The mRNA expression pattern of Smad 2 at all stages of embryonic development was similar in all respect with TGF-β1 type I receptor. On the contrary, Smad 3 and 4 were expressed with high and low level mRNA at the blastocyst stage. In conclusion, it is suggested that TGF-β signaling may be regarded as an important entity during the preimplantation embryo development.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

키워드

저자정보

  • Hak-Jae Chung Hak-Jae chung. Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea, Corresponding author
  • Bong-Ki Kim Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea
  • Jong-Mu Kim Department of Animal Science, Chungbuk National University, Cheongju 361-763, Korea
  • Hyun-Gi Lee Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea
  • Joo-Hee Han Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea
  • Nam-Hyung Kim Department of Animal Science, Chungbuk National University, Cheongju 361-763, Korea
  • Jin-Ki Park Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea
  • Hwan-Hoo Seong Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea
  • Boh Suk Yang Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea
  • Won-Kyong Chang Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea
  • Yeoung Gyu Ko Molecular Endocrinology Laboratory, Department of Animal Biotechnology, National Livestock Research Institute, RDA, Suwon 441-706, Korea, Corresponding author

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