원문정보
초록
영어
In this study, the inhibitory effect of Paecilomyces tenuipes extract on PSA and angiogenesis-related factor expression levels were investigated in human prostate cancer cells, LNCaP. P. tenuipes extract significantly inhibited PSA expression in a dosedependent manner. We also investigated the inhibitory effect of P. tenuipes extract on the expression of angiogenesis-related genes including VEGF, MMP-2, MMP-9, TIMP-1, and TIMP-2. P. tenuipes extract significantly down- regulated the expression of MMP-2 and MMP-9 in a dose-dependent manner. On the contrary, P. tenuipes increased the expression of TIMP-1 and TIMP-2. Our findings indicate that P. tenuipes exhibits an inhibitory effect on angiogenesis in human prostate cancer cells.
목차
서론
재료 및 방법
버섯시료 추출 방법
세포 배양
분석방법
RNA isolation
역전사 반응(Reverse Transcription-Polymerase Chain Reaction, RT-PCR)
PCR정량 분석
통계처리
결과 및 고찰
전립선암세포(LNCaP)에서 눈꽃동충하초 열수 추출물의 PSA mRNA 발현 억제효과
전립선암세포(LNCaP)에서 눈꽃동충하초 열수 추출물의 혈관신생인자 발현 억제효과
적요
감사의 글
References