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Objectives: The purpose of this study was to investigate major satisfaction according to the values and self efficacy of students majoring in health science. Methods: Among the 170 respondents, 25.3% were male and 74.7% were females. The departments were 28.9% of physical therapy, 20.6% of laboratory science, 23.5% of occupational therapy,14.1% of nursing, and dental hygiene 12.9%. Results: In the present study major satisfaction was significantly higher when the higher self efficacy and significantly lower when the higher value. Conclusions: These results indicate that it is necessary to provide contents and appropriate guidance that can enhance the values and self efficacy in order to improve major satisfaction of students majoring in health science.